chemical

Ribavirin

4501

50 mg

118 USD

4501

4501/50

Ribavirin

Blocks eIF4E activity; antiviral guanosine analog

Protein-synthesizing GTPase Compounds

Small Molecules

50 mg

99%

244.2

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Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 M for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 M); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro . Orally available.

4501

broad spectrum antivirals guanosine ribonucleoside analogues analogs mammalian eIF4E inhibits inhibitors translocation cellular redistribution virazole IMPDH inosine monophosphate dehydrogenase inhibitors inhibits COVID-19 SARS-CoV severe acute respirator DNA, RNA and Protein Synthesis Protein-synthesizing GTPases Other Dehydrogenases COVID-19 RNA Polymerase Non-selective Antivirals Coronavirus 4501, Protein-synthesizing GTPase Compounds, GTP ase, EC 3.6.5.3, elongation factor, EF, initiation factor, IF, termination factor

Blocks eIF4E activity; antiviral guanosine analog

1- -D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

C 8 H 12 N 4 O 5

C8H12N4O5

36791-04-5

115

118 USD

Store at +4°C