product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
4501/50
catalog :
4501/50
quantity :
50 mg
price :
149 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
4501
SKU :
4501/50
product name :
Ribavirin
unit size :
50 mg
description :
Blocks eIF4E activity; antiviral guanosine analog
target :
Protein-synthesizing GTPase Compounds
category :
Small Molecules
purity :
99%
observed molecular weight :
244.2
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Ribavirin is an antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 M for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 M); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro . Orally available.
top caption :
Blocks eIF4E activity; antiviral guanosine analog
extended description :
Blocks eIF4E activity; antiviral guanosine analog
chemical name text :
1- -D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
formula :
C8H12N4O5
formula text :
C8H12N4O5
cas num :
36791-04-5
USD :
149 USD
product details :
Blocks eIF4E activity; antiviral guanosine analog
storage :
Store at +4░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK