Cercosporamide | Tocris Bioscience 4500/500U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cercosporamide

catalog :

4500/500U

quantity :

500 ug

price :

243 USD

citations: 1

Reference
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed publisher

product information

brand :

Tocris

master code :

4500

SKU :

4500/500U

product name :

Cercosporamide

target :

Mnk Inhibitors

category :

Small Molecules

unit sizes :

500 ug

purity :

96%

observed molecular weight :

331.28

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro . Also inhibits Pkc1. Orally bioavailable.

extended description :

Potent Mnk2 inhibitor

chemical name text :

(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide

formula :

C 16 H 13 NO 7

formula text :

C16H13NO7

cas num :

131436-22-1

USD :

243 USD

product details :

Potent Mnk2 inhibitor

storage :

Store at -20°C