4500/331U | Tocris Bioscience 4500/331U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4500/331U

catalog :

4500/331U

quantity :

331 ug

price :

361 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Xu S, Tang J, Wang C, Liu J, Fu Y, Luo Y. CXCR7 promotes melanoma tumorigenesis via Src kinase signaling. Cell Death Dis. 2019;10:191 pubmed publisher
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed publisher
Lock R, Ingraham R, Maertens O, Miller A, Weledji N, Legius E, et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016;126:2181-90 pubmed publisher
Hsu K, Guan B, Cheng X, Guan D, Lam M, Hatzoglou M, et al. Translational control of PML contributes to TNFÎ±-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death Differ. 2016;23:469-83 pubmed publisher
Wu H, Hu C, Wang A, Weisberg E, Chen Y, Yun C, et al. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 2016;30:173-81 pubmed publisher

image

image 1 :

Cat.No. 4500 - Cercosporamide C16H13NO7 CAS No. 131436-22-1

product information

master code :

4500

SKU :

4500/331U

product name :

Cercosporamide

unit size :

331 ug

description :

Potent Mnk2 inhibitor

target :

Mnk Inhibitors

category :

Small Molecules

purity :

96%

observed molecular weight :

331.28

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro . Also inhibits Pkc1. Orally bioavailable.

top caption :

Potent Mnk2 inhibitor

extended description :

Potent Mnk2 inhibitor

chemical name text :

(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide

formula :

C16H13NO7

formula text :

C16H13NO7

cas num :

131436-22-1

USD :

361 USD

product details :

Potent Mnk2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage