Y 11 | Tocris Bioscience 4498 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Y 11

catalog :

4498

quantity :

10 mg (also 50 mg)

price :

123 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Keasey M, Jia C, Pimentel L, Sante R, Lovins C, Hagg T. Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci. 2018;131: pubmed publisher
Robinson S, Guyon L, Nevalainen J, Toriseva M, Akerfelt M, Nees M. Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields. PLoS ONE. 2015;10:e0143798 pubmed publisher
Brown C, Brodsky A, Freiman R. Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res. 2015;13:78-85 pubmed publisher

product information

brand :

Tocris

master code :

4498

SKU :

4498/10

product name :

Y 11

description :

Potent and selective FAK inhibitor

target :

Focal Adhesion Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

265.15

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 M). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

catalog number base :

4498

product keywords :

potent focal adhesion kinase FAK inhibits inhibitors autophosphorylation selective Y11 Focal Adhesion Kinase 4498,

extended description :

Potent and selective FAK inhibitor

chemical name text :

1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide

formula :

C 8 H 17 N 4 OBr

formula text :

C8H17N4OBr

cas num :

1086639-59-9

2020 USD :

153

2021 USD :

123 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage