4491/10 | Tocris Bioscience 4491/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4491/10

catalog :

4491/10

quantity :

10 mg (also 50 mg)

price :

242 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi Pocachard E, Minlebaev M, et al. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun. 2014;5:4563 pubmed publisher

product information

master code :

4491

SKU :

4491/10

product name :

DQP 1105

unit size :

10 mg (also 50 mg)

description :

GluN2C/GluN2D-selective NMDA antagonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

purity :

97%

observed molecular weight :

558.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 M, respectively). Reduces frequency of channel opening. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

GluN2C/GluN2D-selective NMDA antagonist

extended description :

GluN2C/GluN2D-selective NMDA antagonist

chemical name text :

5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro- -oxo-1H-pyrazole-1-butanoic acid

formula :

C29H24BrN3O4

formula text :

C29H24BrN3O4

cas num :

380560-89-4

USD :

242 USD

product details :

GluN2C/GluN2D-selective NMDA antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage