DBZ | Tocris Bioscience 4489 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DBZ

catalog :

4489

quantity :

10 mg (also 50 mg)

price :

260 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Santos C, Lapi E, Martínez de Villarreal J, Álvaro Espinosa L, Fernández Barral A, Barbachano A, et al. Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun. 2019;10:4407 pubmed publisher
Page D, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert S. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep. 2019;27:3139-3151.e5 pubmed publisher
Chen S, Giannakou A, Wyman S, Gruzas J, Golas J, Zhong W, et al. Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture. Proc Natl Acad Sci U S A. 2018;115:E11671-E11680 pubmed publisher
Marshall J, Barnes A, Genever P. Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel). 2018;5: pubmed publisher
Khan O, Carvalho J, Spencer Dene B, Mitter R, Frith D, Snijders A, et al. The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. J Clin Invest. 2018;128:1326-1337 pubmed publisher
Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, et al. Stage-specific effects of Notch activation during skeletal myogenesis. elife. 2016;5: pubmed publisher
Bi P, Yue F, Karki A, Castro B, Wirbisky S, Wang C, et al. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med. 2016;213:2019-37 pubmed publisher
Ihara S, Hirata Y, Serizawa T, Suzuki N, Sakitani K, Kinoshita H, et al. TGF-? Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota. J Immunol. 2016;196:4603-13 pubmed publisher
Bi P, Shan T, Liu W, Yue F, Yang X, Liang X, et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med. 2014;20:911-8 pubmed publisher
Shah M, Zerlin M, Li B, Herzog T, KITAJEWSKI J, Wright J. The role of Notch and gamma-secretase inhibition in an ovarian cancer model. Anticancer Res. 2013;33:801-8 pubmed

product information

brand :

Tocris

master code :

4489

SKU :

4489/10

product name :

DBZ

description :

-secretase inhibitor; inhibits Notch pathway

target :

Secretase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

463.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of -secretase. Blocks Notch cleavage (IC50 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes.

catalog number base :

4489

product keywords :

Notch inhibitors inhibits gamma γ g-secretases signaling signalling pathways gamma-secretase amyloid stem cells iPSCs induced pluripotent reprogramming dedifferentiation Dibenzazepine Gamma-Secretase Stem Cell Reprogramming 4489,

extended description :

-secretase inhibitor; inhibits Notch pathway

chemical name text :

N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

formula :

C 26 H 23 F 2 N 3 O 3

formula text :

C26H23F2N3O3

cas num :

209984-56-5

2020 USD :

247

2021 USD :

260 USD

alt names :

Dibenzazepine

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage