4489/10 | Tocris Bioscience 4489/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4489/10

catalog :

4489/10

quantity :

10 mg (also 50 mg)

price :

342 USD

more info or order :

Tocris Bioscience product webpage

citations: 22

Reference
Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms J, et al. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. elife. 2022;11: pubmed publisher
Jeong M, Ocwieja K, Han D, Wackym P, Zhang Y, Brown A, et al. Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction. Commun Med (Lond). 2021;1:44 pubmed publisher
Garcia Alonso L, Handfield L, Roberts K, Nikolakopoulou K, Fernando R, Gardner L, et al. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Nat Genet. 2021;53:1698-1711 pubmed publisher
Schenk M, Humphrey S, Hossain A, Revill M, Pearsall S, Lallo A, et al. Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Nat Commun. 2021;12:6652 pubmed publisher
Huang L, Desai R, Conrad D, Leite N, Akshinthala D, Lim C, et al. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021;28:1090-1104.e6 pubmed publisher
Bayerl J, Ayyash M, Shani T, Manor Y, Gafni O, Massarwa R, et al. Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell. 2021;: pubmed publisher
Steffes L, Froistad A, Andruska A, Boehm M, McGlynn M, Zhang F, et al. A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions. Circulation. 2020;142:1545-1561 pubmed publisher
Baulies A, Angelis N, Foglizzo V, Danielsen E, Patel H, Novellasdemunt L, et al. The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory Lineages. Gastroenterology. 2020;159:1328-1341.e3 pubmed publisher
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Ramachandran P, Dobie R, Wilson Kanamori J, Dora E, Henderson B, Luu N, et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 2019;575:512-518 pubmed publisher
Santos C, Lapi E, Martínez de Villarreal J, Álvaro Espinosa L, Fernández Barral A, Barbachano A, et al. Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun. 2019;10:4407 pubmed publisher
Page D, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert S. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep. 2019;27:3139-3151.e5 pubmed publisher
Chen S, Giannakou A, Wyman S, Gruzas J, Golas J, Zhong W, et al. Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture. Proc Natl Acad Sci U S A. 2018;115:E11671-E11680 pubmed publisher
Marshall J, Barnes A, Genever P. Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel). 2018;5: pubmed publisher
Högström J, Heino S, Kallio P, Lähde M, Leppänen V, Balboa D, et al. Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. Cancer Res. 2018;78:5820-5832 pubmed publisher
Khan O, Carvalho J, Spencer Dene B, Mitter R, Frith D, Snijders A, et al. The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. J Clin Invest. 2018;128:1326-1337 pubmed publisher
Cogger K, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, et al. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun. 2017;8:331 pubmed publisher
Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, et al. Stage-specific effects of Notch activation during skeletal myogenesis. elife. 2016;5: pubmed publisher
Bi P, Yue F, Karki A, Castro B, Wirbisky S, Wang C, et al. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med. 2016;213:2019-37 pubmed publisher
Ihara S, Hirata Y, Serizawa T, Suzuki N, Sakitani K, Kinoshita H, et al. TGF-? Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota. J Immunol. 2016;196:4603-13 pubmed publisher
Bi P, Shan T, Liu W, Yue F, Yang X, Liang X, et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med. 2014;20:911-8 pubmed publisher
Shah M, Zerlin M, Li B, Herzog T, KITAJEWSKI J, Wright J. The role of Notch and gamma-secretase inhibition in an ovarian cancer model. Anticancer Res. 2013;33:801-8 pubmed

product information

master code :

4489

SKU :

4489/10

product name :

DBZ

unit size :

10 mg (also 50 mg)

description :

-secretase inhibitor; inhibits Notch pathway

target :

Secretase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

463.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DBZ is an inhibitor of -secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC . In an animal model of Alzheimer s disease, DBZ inhibits the cleavage of amyloid precursor protein into A 40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions. . DBZ synthesized to Ancillary Material Grade also available.

top caption :

-secretase inhibitor; inhibits Notch pathway

extended description :

-secretase inhibitor; inhibits Notch pathway

chemical name text :

N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

formula :

C26H23F2N3O3

formula text :

C26H23F2N3O3

cas num :

209984-56-5

USD :

342 USD

product details :

-secretase inhibitor; inhibits Notch pathway

alt names :

Dibenzazepine,YO-01027

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage