(+/-)-AMG 487 | Tocris Bioscience 4487 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(+/-)-AMG 487

catalog :

4487

quantity :

10 mg (also 50 mg)

price :

272 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Guo Y, Chiu Y, Chen C, Wang H. Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Res Ther. 2018;9:281 pubmed publisher
Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher

product information

brand :

Tocris

master code :

4487

SKU :

4487/10

product name :

(+/-)-AMG 487

description :

CXCR3 antagonist; inhibits cell migration and metastasis

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

603.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. . This product is racemic.

catalog number base :

4487

product keywords :

CXCR3 chemokine receptors antagonists inhibitors inhibits cell migration metastasis -AMG487 -AMG_487 Chemokine CXC Receptors 4487,

extended description :

CXCR3 antagonist; inhibits cell migration and metastasis

chemical name text :

N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

formula :

C 32 H 28 F 3 N 5 O 4

formula text :

C32H28F3N5O4

cas num :

947536-03-0

2020 USD :

259

2021 USD :

272 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage