(+/-)-AMG 487 | Tocris Bioscience 4487/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(+/-)-AMG 487

catalog :

4487/10

quantity :

10 mg (also 50 mg)

price :

358 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Weinstock A, RAHMAN K, Yaacov O, Nishi H, Menon P, Nikain C, et al. Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis. elife. 2021;10: pubmed publisher
Pein M, Insua Rodríguez J, Hongu T, Riedel A, Meier J, Wiedmann L, et al. Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs. Nat Commun. 2020;11:1494 pubmed publisher
Walsh C, Hill R, Schwendinger Schreck J, Deguine J, Brock E, Kucirek N, et al. Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. elife. 2019;8: pubmed publisher
Ojha A, Bhasym A, Mukherjee S, Annarapu G, Bhakuni T, Akbar I, et al. Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine. 2019;39:332-347 pubmed publisher
Guo Y, Chiu Y, Chen C, Wang H. Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Res Ther. 2018;9:281 pubmed publisher
Gordón Alonso M, Hirsch T, Wildmann C, van der Bruggen P. Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun. 2017;8:793 pubmed publisher
Ortner D, Tripp C, Komenda K, Dubrac S, Zelger B, Hermann M, et al. Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis. Oncoimmunology. 2017;6:e1260215 pubmed publisher
Jin W, Kim B, Kim D, Park Choo H, Kim H, Ha H, et al. NF-ÎºB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells. Exp Mol Med. 2017;49:e295 pubmed publisher
Gouwy M, Ruytinx P, Radice E, Claudi F, Van Raemdonck K, Bonecchi R, et al. CXCL4 and CXCL4L1 Differentially Affect Monocyte Survival and Dendritic Cell Differentiation and Phagocytosis. PLoS ONE. 2016;11:e0166006 pubmed publisher

product information

brand :

Tocris

master code :

4487

SKU :

4487/10

product name :

(+/-)-AMG 487

unit size :

10 mg (also 50 mg)

seo description :

CXCR3 antagonist; inhibits cell migration and metastasis

target :

Chemokine Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

603.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( )-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. . This product is racemic.

top caption :

CXCR3 antagonist; inhibits cell migration and metastasis

extended description :

CXCR3 antagonist; inhibits cell migration and metastasis

chemical name text :

N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

formula :

C32H28F3N5O4

formula text :

C32H28F3N5O4

cas num :

947536-03-0

USD :

358 USD

product details :

CXCR3 antagonist; inhibits cell migration and metastasis

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage