P 22077 | Tocris Bioscience 4485 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

P 22077

catalog :

4485

quantity :

10 mg (also 50 mg)

price :

201 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ji L, Lu B, Zamponi R, Charlat O, Aversa R, Yang Z, et al. USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun. 2019;10:4184 pubmed publisher
Lecona E, Rodriguez Acebes S, Specks J, López Contreras A, Ruppen I, Murga M, et al. USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016;23:270-7 pubmed publisher
Lecona E, Narendra V, Reinberg D. USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol. 2015;35:1157-68 pubmed publisher

product information

brand :

Tocris

master code :

4485

SKU :

4485/10

product name :

P 22077

description :

USP7 inhibitor

target :

Deubiquitinating Enzyme Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

315.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 M); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro . Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

catalog number base :

4485

product keywords :

P22077 inhibitors inhibits ubiquitin-specific proteases USP7 DUB HDM2 claspin ubiquitin deubiquitination anticancer hausp Deubiquitinating Enzymes 4485,, DUB, Deubiquitinase

extended description :

USP7 inhibitor

chemical name text :

1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone

formula :

C 12 H 7 F 2 NO 3 S 2

formula text :

C12H7F2NO3S2

cas num :

1247819-59-5

2020 USD :

195

2021 USD :

201 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage