STF 31 | Tocris Bioscience 4484 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

STF 31

catalog :

4484

quantity :

10 mg (also 50 mg)

price :

225 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Fons N, Sundaram R, Breuer G, Peng S, McLean R, Kalathil A, et al. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019;10:3790 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Queckborner S, Turnbull A, Michie C, et al. Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment. BMC Cancer. 2018;18:636 pubmed publisher
Thwe P, Pelgrom L, Cooper R, Beauchamp S, Reisz J, D Alessandro A, et al. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2017;26:558-567.e5 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Marston H, Turnbull A, Langdon S. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget. 2015;6:25677-95 pubmed publisher
Kropp E, Oleson B, Broniowska K, Bhattacharya S, Chadwick A, Diers A, et al. Inhibition of an NADâº salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl Med. 2015;4:483-93 pubmed publisher

product information

brand :

Tocris

master code :

4484

SKU :

4484/10

product name :

STF 31

description :

NAMPT inhibitor; also GLUT1 inhibitor

target :

Glucose Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

423.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.

catalog number base :

4484

product keywords :

STF31 glut1 glucose transporters inhibitors inhibits glucose uptake slc2a1 Glucose Transporters NAMPT ESCs and iPSC 4484,

extended description :

NAMPT inhibitor; also GLUT1 inhibitor

chemical name text :

4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide

formula :

C 23 H 25 N 3 O 3 S

formula text :

C23H25N3O3S

cas num :

724741-75-7

2020 USD :

218

2021 USD :

225 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage