STF 31 | Tocris Bioscience 4484/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

STF 31

catalog :

4484/10

quantity :

10 mg (also 50 mg)

price :

252 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Qin S, Wang G, Chen L, Geng H, Zheng Y, Xia C, et al. Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression. PLoS Genet. 2023;19:e1010629 pubmed publisher
Fons N, Sundaram R, Breuer G, Peng S, McLean R, Kalathil A, et al. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019;10:3790 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Queckborner S, Turnbull A, Michie C, et al. Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment. BMC Cancer. 2018;18:636 pubmed publisher
Thwe P, Pelgrom L, Cooper R, Beauchamp S, Reisz J, D Alessandro A, et al. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2017;26:558-567.e5 pubmed publisher
Molina S, Moriarty H, Infield D, Imhoff B, Vance R, Kim A, et al. Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. Am J Physiol Lung Cell Mol Physiol. 2017;312:L688-L702 pubmed publisher
Xintaropoulou C, Ward C, Wise A, Marston H, Turnbull A, Langdon S. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget. 2015;6:25677-95 pubmed publisher
Kropp E, Oleson B, Broniowska K, Bhattacharya S, Chadwick A, Diers A, et al. Inhibition of an NADâº salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl Med. 2015;4:483-93 pubmed publisher
Shajahan Haq A, Cook K, Schwartz Roberts J, Eltayeb A, Demas D, Wärri A, et al. MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer. Mol Cancer. 2014;13:239 pubmed publisher

product information

brand :

Tocris

master code :

4484

SKU :

4484/10

product name :

STF 31

unit size :

10 mg (also 50 mg)

seo description :

NAMPT inhibitor; also GLUT1 inhibitor

target :

Glucose Transporter Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

423.53

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

STF 31 is an inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.

top caption :

NAMPT inhibitor; also GLUT1 inhibitor

extended description :

NAMPT inhibitor; also GLUT1 inhibitor

chemical name text :

4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide

formula :

C23H25N3O3S

formula text :

C23H25N3O3S

cas num :

724741-75-7

USD :

252 USD

product details :

NAMPT inhibitor; also GLUT1 inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage