Ki 20227 | Tocris Bioscience 4481/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ki 20227

catalog :

4481/10

quantity :

10 mg (also 50 mg)

price :

379 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher

product information

brand :

Tocris

master code :

4481

SKU :

4481/10

product name :

Ki 20227

unit size :

10 mg (also 50 mg)

seo description :

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

target :

Additional RTK Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

480.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFR and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

top caption :

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

extended description :

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

chemical name text :

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N -[1-(2-thiazolyl)ethyl]urea

formula :

C24H24N4O5S

formula text :

C24H24N4O5S

cas num :

623142-96-1

USD :

379 USD

product details :

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage