4mu8C | Tocris Bioscience 4479/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4mu8C

catalog :

4479/10

quantity :

10 mg (also 50 mg)

price :

256 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Eesmaa A, Yu L, G xf6 xf6 s H, Danilova T, N xf5 ges K, Pakarinen E, et al. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int J Mol Sci. 2022;23: pubmed publisher
Huis In t Veld L, Ho N, Wassink M, den Brok M, Adema G. Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation. Cell Mol Life Sci. 2022;79:231 pubmed publisher
Eesmaa A, Yu L, Göös H, Nõges K, Kovaleva V, Hellman M, et al. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem. 2021;:100295 pubmed publisher
Lee D, Sevits K, Battson M, Wei Y, Cox York K, Gentile C. Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells. PLoS ONE. 2019;14:e0226940 pubmed publisher
Amin Wetzel N, Neidhardt L, Yan Y, Mayer M, Ron D. Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. elife. 2019;8: pubmed publisher
Mogilenko D, Haas J, L homme L, Fleury S, Quemener S, Levavasseur M, et al. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019;177:1201-1216.e19 pubmed publisher
Marchelletta R, Yu J, Moon C, Kim M. Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology. Curr Protoc Pharmacol. 2019;85:e54 pubmed publisher
Rosen D, Seki S, Fernandez Castaneda A, Beiter R, Eccles J, Woodfolk J, et al. Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med. 2019;11: pubmed publisher
Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T. Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation. Cell Physiol Biochem. 2018;47:1936-1950 pubmed publisher
Amin Wetzel N, Saunders R, Kamphuis M, Rato C, Preissler S, Harding H, et al. A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell. 2017;171:1625-1637.e13 pubmed publisher
Beisel C, Ziegler S, Martrus Zapater G, Chapel A, Griesbeck M, Hildebrandt H, et al. TLR7-mediated activation of XBP1 correlates with the IFNÎ± production in humans. Cytokine. 2017;94:55-58 pubmed publisher

product information

brand :

Tocris

master code :

4479

SKU :

4479/10

product name :

4mu8C

unit size :

10 mg (also 50 mg)

seo description :

Inhibits IRE1 endoribonuclease activity

target :

IRE1 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

204.18

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

4 8C is a selective inhibitor of IRE1 ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1 . Inactivates IRE1 -mediated mRNA degradation. Displays no effect on the IRE1 -related endoribonuclease RNase L.

top caption :

Inhibits IRE1 endoribonuclease activity

extended description :

Inhibits IRE1 endoribonuclease activity

chemical name text :

7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

formula :

C11H8O4

formula text :

C11H8O4

cas num :

14003-96-4

USD :

256 USD

product details :

Inhibits IRE1 endoribonuclease activity

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage