20(S)-Hydroxycholesterol | Tocris Bioscience 4474/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

20(S)-Hydroxycholesterol

catalog :

4474/10

quantity :

10 mg

price :

232 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Yalcınkaya M, Kerksiek A, Gebert K, Annema W, Sibler R, Radosavljevic S, et al. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened. J Lipid Res. 2020;61:492-504 pubmed publisher
Carmona Fontaine C, Deforet M, Akkari L, Thompson C, Joyce J, Xavier J. Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci U S A. 2017;114:2934-2939 pubmed publisher
Nachtergaele S, Mydock L, Krishnan K, Rammohan J, Schlesinger P, Covey D, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012;8:211-20 pubmed publisher

product information

brand :

Tocris

master code :

4474

SKU :

4474/10

product name :

20(S)-Hydroxycholesterol

unit size :

10 mg

seo description :

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

target :

Hedgehog Signaling Activators

category :

Small Molecules

purity :

95%

observed molecular weight :

402.65

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

20( S )-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC50 ~ 3 M for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).

top caption :

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

extended description :

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

chemical name text :

(3 )-Cholest-5-ene-3,20-diol

formula :

C27H46O2

formula text :

C27H46O2

cas num :

516-72-3

USD :

232 USD

product details :

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage