A 804598 | Tocris Bioscience 4473 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 804598

catalog :

4473

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher

product information

brand :

Tocris

master code :

4473

SKU :

4473/10

product name :

A 804598

description :

Potent and selective P2X7 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

315.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 M for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

catalog number base :

4473

product keywords :

A804598 purinergic receptors P2X7 antagonists inhibitors inhibits potent selective competitive high affinity P2X Receptors 4473,

extended description :

Potent and selective P2X7 antagonist

chemical name text :

N-Cyano-N -[(1S)-1-phenylethyl]-N -5-quinolinyl-guanidine

formula :

C 19 H 17 N 5

formula text :

C19H17N5

cas num :

1125758-85-1

2020 USD :

187

2021 USD :

195 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage