A 804598 | Tocris Bioscience 4473/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 804598

catalog :

4473/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Mekala N, Gheewala N, Rom S, Sriram U, Persidsky Y. Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells. Antioxidants (Basel). 2022;11: pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Janks L, Sharma C, Egan T. A central role for P2X7 receptors in human microglia. J Neuroinflammation. 2018;15:325 pubmed publisher
He Y, Taylor N, Fourgeaud L, Bhattacharya A. The role of microglial P2X7: modulation of cell death and cytokine release. J Neuroinflammation. 2017;14:135 pubmed publisher
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher

product information

brand :

Tocris

master code :

4473

SKU :

4473/10

product name :

A 804598

unit size :

10 mg (also 50 mg)

seo description :

Potent and selective P2X7 antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

315.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 M for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

top caption :

Potent and selective P2X7 antagonist

extended description :

Potent and selective P2X7 antagonist

chemical name text :

N-Cyano-N -[(1S)-1-phenylethyl]-N -5-quinolinyl-guanidine

formula :

C19H17N5

formula text :

C19H17N5

cas num :

1125758-85-1

USD :

245 USD

product details :

Potent and selective P2X7 antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage