BAY 60-6583 | Tocris Bioscience 4472 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 60-6583

catalog :

4472

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Shih Y, Liu M, Kwon S, Iida M, Gong Y, Sangaj N, et al. Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. Sci Adv. 2019;5:eaax1387 pubmed publisher
De Nuccio C, Bernardo A, Ferrante A, Pepponi R, Martire A, Falchi M, et al. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 2019;9:9782 pubmed publisher
Mertens T, Hanmandlu A, Tu L, Phan C, Collum S, Chen N, et al. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension. Front Physiol. 2018;9:555 pubmed publisher
Jain S, Panyutin A, Liu N, Xiao C, Pinol R, Pundir P, et al. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018;315:E357-E366 pubmed publisher
Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
Asano T, Tanaka K, Tada A, Shimamura H, Tanaka R, Maruoka H, et al. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci Rep. 2017;7:40214 pubmed publisher
Merighi S, Bencivenni S, Vincenzi F, Varani K, Borea P, Gessi S. A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway. Pharmacol Res. 2017;117:9-19 pubmed publisher
Wilson J, Prokop J, Lorimer E, Ntantie E, Williams C. Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. J Mol Biol. 2016;428:4929-4945 pubmed publisher
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher
Aherne C, Saeedi B, Collins C, Masterson J, McNamee E, Perrenoud L, et al. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015;8:1324-38 pubmed publisher
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia. 2013;15:1400-9 pubmed

product information

brand :

Tocris

master code :

4472

SKU :

4472/10

product name :

BAY 60-6583

description :

Potent A2B agonist; cardioprotective

target :

Adenosine A2b Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

379.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

catalog number base :

4472

product keywords :

BAY60-6583 adenosine A2B receptor agonists potent cAMP cardioprotective ischemia superoxide neutrophils ERK1/2 biased agonism Adenosine A2B Receptors 4472,

extended description :

Potent A2B agonist; cardioprotective

chemical name text :

2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide

formula :

C 19 H 17 N 5 O 2 S

formula text :

C19H17N5O2S

cas num :

910487-58-0

2020 USD :

205

2021 USD :

216 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage