product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
BAY 60-6583
catalog :
4472/10
quantity :
10 mg (also 50 mg)
price :
277 USD
more info or order :
citations: 22
Reference
El Naccache D, Chen F, Palma M, Lemenze A, Fischer M, Wu W, et al. Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells. Cell Rep. 2022;40:111150 pubmed publisher
Cooper S, Wragg E, Pannucci P, Soave M, Hill S, Woolard J. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB J. 2022;36:e22214 pubmed publisher
S xe1 nchez Melgar A, Mu xf1 oz L xf3 pez S, Albasanz J, Mart xed n M. Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells. Front Neurosci. 2021;15:702817 pubmed publisher
Rueda P, Merlin J, Chimenti S, Feletou M, Paysant J, White P, et al. Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure. Front Pharmacol. 2021;12:628060 pubmed publisher
Gnad T, Navarro G, Lahesmaa M, Reverte Salisa L, Copperi F, Cordomi A, et al. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. Cell Metab. 2020;32:56-70.e7 pubmed publisher
Angioni R, Liboni C, Herkenne S, Sánchez Rodríguez R, Borile G, Marcuzzi E, et al. CD73+ extracellular vesicles inhibit angiogenesis through adenosine A2B receptor signalling. J Extracell Vesicles. 2020;9:1757900 pubmed publisher
Fujimoto K, Shioi A, Miki Y, Kakutani Y, Morioka T, Shoji T, et al. Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor. Tohoku J Exp Med. 2019;249:275-283 pubmed publisher
Kayhan M, Koyas A, Akdemir I, Savas A, Cekic C. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol. 2019;203:3247-3255 pubmed publisher
Shih Y, Liu M, Kwon S, Iida M, Gong Y, Sangaj N, et al. Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. Sci Adv. 2019;5:eaax1387 pubmed publisher
De Nuccio C, Bernardo A, Ferrante A, Pepponi R, Martire A, Falchi M, et al. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 2019;9:9782 pubmed publisher
Mertens T, Hanmandlu A, Tu L, Phan C, Collum S, Chen N, et al. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension. Front Physiol. 2018;9:555 pubmed publisher
Jain S, Panyutin A, Liu N, Xiao C, Pinol R, Pundir P, et al. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018;315:E357-E366 pubmed publisher
Nakashima K, Iwao K, Inoue T, Haga A, Tsutsumi T, Mochita M, et al. Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells. Exp Eye Res. 2018;170:160-168 pubmed publisher
Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
Asano T, Tanaka K, Tada A, Shimamura H, Tanaka R, Maruoka H, et al. Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci Rep. 2017;7:40214 pubmed publisher
Merighi S, Bencivenni S, Vincenzi F, Varani K, Borea P, Gessi S. A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway. Pharmacol Res. 2017;117:9-19 pubmed publisher
Wilson J, Prokop J, Lorimer E, Ntantie E, Williams C. Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. J Mol Biol. 2016;428:4929-4945 pubmed publisher
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher
Cohen H, Ward A, Hamidzadeh K, Ravid K, Mosser D. IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. J Immunol. 2015;195:3828-37 pubmed publisher
Aherne C, Saeedi B, Collins C, Masterson J, McNamee E, Perrenoud L, et al. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015;8:1324-38 pubmed publisher
Francois V, Shehade H, Acolty V, Preyat N, Delrée P, Moser M, et al. Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection. Mucosal Immunol. 2015;8:773-84 pubmed publisher
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia. 2013;15:1400-9 pubmed
product information
brand :
Tocris
master code :
4472
SKU :
4472/10
product name :
BAY 60-6583
unit size :
10 mg (also 50 mg)
seo description :
Potent partial A2B agonist; cardioprotective
target :
Adenosine A2b Receptor Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
379.44
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BAY 60-6583 is a partial agonist at adenosine A2B receptors (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. BAY 60-6583 antagonizes the effect of NECA (Cat. No. 1691) and adenosine (Cat. No. 3624) in cAMP accumulation assays. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.
top caption :
Potent partial A2B agonist; cardioprotective
extended description :
Potent partial A2B agonist; cardioprotective
chemical name text :
2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
formula :
C19H17N5O2S
formula text :
C19H17N5O2S
cas num :
910487-58-0
USD :
277 USD
product details :
Potent partial A2B agonist; cardioprotective
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK