TCS ERK 11e | Tocris Bioscience 4465/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TCS ERK 11e

catalog :

4465/10

quantity :

10 mg

price :

368 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lenz T, St xfc hler K. Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses. Int J Mol Sci. 2022;23: pubmed publisher
Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundb xe4 ck T, Nordlund P, et al. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc. 2014;9:2100-22 pubmed publisher

product information

brand :

Tocris

master code :

4465

SKU :

4465/10

product name :

TCS ERK 11e

unit size :

10 mg

seo description :

Potent and selective ERK2 inhibitor

target :

ERK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

500.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TCS ERK 11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are 2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

top caption :

Potent and selective ERK2 inhibitor

extended description :

Potent and selective ERK2 inhibitor

chemical name text :

4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

formula :

C24H20Cl2FN5O2

formula text :

C24H20Cl2FN5O2

cas num :

896720-20-0

USD :

368 USD

product details :

Potent and selective ERK2 inhibitor

alt names :

VX 11e

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage