IOX 1 | Tocris Bioscience 4464/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IOX 1

catalog :

4464/10

quantity :

10 mg (also 50 mg)

price :

206 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher
Massett M, Monaghan L, Patterson S, Mannion N, Bunschoten R, Hoose A, et al. A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival. Cell Death Dis. 2021;12:573 pubmed publisher
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed publisher

product information

brand :

Tocris

master code :

4464

SKU :

4464/10

product name :

IOX 1

unit size :

10 mg (also 50 mg)

seo description :

Histone demethylase inhibitor; cell permeable

target :

Histone Demethylase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

189.17

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

top caption :

Histone demethylase inhibitor; cell permeable

extended description :

Histone demethylase inhibitor; cell permeable

chemical name text :

8-Hydroxy-5-quinolinecarboxylic acid

formula :

C10H7NO3

formula text :

C10H7NO3

cas num :

5852-78-8

USD :

206 USD

product details :

Histone demethylase inhibitor; cell permeable

alt names :

5-carboxy-8HQ

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage