SR 8278 | Tocris Bioscience 4463 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 8278

catalog :

4463

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Parker C, Galmozzi A, Wang Y, Correia B, Sasaki K, Joslyn C, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168:527-541.e29 pubmed publisher

product information

brand :

Tocris

master code :

4463

SKU :

4463/10

product name :

SR 8278

description :

Rev-Erb antagonist

target :

Nuclear Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

361.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rev-Erb antagonist; inhibits Rev-Erb transcriptional repression (EC50 = 0.47 M). Blocks activity of Rev-Erb agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

catalog number base :

4463

product keywords :

SR8278 REV-ERB heme nuclear receptors antagonists inhibits glucose regulation Rev-Erb Receptors 4463,

extended description :

Rev-Erb antagonist

chemical name text :

1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

formula :

C 18 H 19 NO 3 S 2

formula text :

C18H19NO3S2

cas num :

1254944-66-5

2020 USD :

187

2021 USD :

195 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage