SR 8278 | Tocris Bioscience 4463/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 8278

catalog :

4463/10

quantity :

10 mg (also 50 mg)

price :

253 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Yuan B, Shi K, Zha J, Cai Y, Gu Y, Huang K, et al. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis. 2023;14:51 pubmed publisher
Zhou G, Winn E, Nguyen D, Kasten E, Petroff M, Hoffmann H. Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia. Sci Rep. 2022;12:17856 pubmed publisher
Lee S, Yang H. Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson's Disease Model. Biomol Ther (Seoul). 2022;30:409-417 pubmed publisher
Parker C, Galmozzi A, Wang Y, Correia B, Sasaki K, Joslyn C, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168:527-541.e29 pubmed publisher

product information

brand :

Tocris

master code :

4463

SKU :

4463/10

product name :

SR 8278

unit size :

10 mg (also 50 mg)

seo description :

Rev-Erb antagonist

target :

Nuclear Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

361.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SR 8278 is a Rev-Erb antagonist; inhibits Rev-Erb transcriptional repression (EC50 = 0.47 M). Blocks activity of Rev-Erb agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

top caption :

Rev-Erb antagonist

extended description :

Rev-Erb antagonist

chemical name text :

1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

formula :

C18H19NO3S2

formula text :

C18H19NO3S2

cas num :

1254944-66-5

USD :

253 USD

product details :

Rev-Erb antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage