VU 29 | Tocris Bioscience 4458 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 29

catalog :

4458

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Pollard M, Bartolome J, Conn P, Steckler T, Shaban H. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 2014;28:935-46 pubmed publisher

product information

brand :

Tocris

master code :

4458

SKU :

4458/10

product name :

VU 29

description :

Potent positive allosteric modulator of mGlu5 receptors

target :

Group I mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

384.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent allosteric potentiator at the rat mGlu5 receptor (EC50 = 9 nM); binds to the MPEP (Cat. No. 1212) allosteric site (Ki app = 244 nM). Selective for mGlu5 over mGlu1 and mGlu2 receptors (EC50 values are 557 nM and 1.51 M for mGlu1 and mGlu2 respectively). Potentiates both DHPG-induced LTP and threshold -burst stimulation (TBS)-induced LTP in rat hippocampal slices. Analog of CDPPB (Cat. No. 3235).

catalog number base :

4458

product keywords :

VU29 mGlu5 mGluR5 pams positive allosteric potentiators modulators glutamate receptors Glutamate (Metabotropic) Group I Receptors 4458,

extended description :

Potent positive allosteric modulator of mGlu5 receptors

chemical name text :

N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide

formula :

C 22 H 16 N 4 O 3

formula text :

C22H16N4O3

cas num :

890764-36-0

2020 USD :

199

2021 USD :

199 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage