GDC 0879 | Tocris Bioscience 4453/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GDC 0879

catalog :

4453/10

quantity :

10 mg (also 50 mg)

price :

331 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ferreira A, Casamento A, Carrillo Roas S, Halff E, Panambalana J, Subramaniam S, et al. Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun. 2021;12:2424 pubmed publisher

product information

brand :

Tocris

master code :

4453

SKU :

4453/10

product name :

GDC 0879

unit size :

10 mg (also 50 mg)

seo description :

Potent B-Raf inhibitor

target :

Raf Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

334.37

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GDC 0879 is a potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.

top caption :

Potent B-Raf inhibitor

extended description :

Potent B-Raf inhibitor

chemical name text :

2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime

formula :

C19H18N4O2

formula text :

C19H18N4O2

cas num :

905281-76-7

USD :

331 USD

product details :

Potent B-Raf inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage