IOX 2 | Tocris Bioscience 4451/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IOX 2

catalog :

4451/10

quantity :

10 mg (also 50 mg)

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher
Torosyan R, Huang S, Bommi P, Tiwari R, An S, Schönfeld M, et al. Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway. Cell Rep. 2021;36:109547 pubmed publisher

product information

brand :

Tocris

master code :

4451

SKU :

4451/10

product name :

IOX 2

unit size :

10 mg (also 50 mg)

seo description :

Potent, selective HIF-1 prolyl hydroxylase-2 (PHD2) inhibitor

target :

Hydroxylase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

352.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IOX 2 is a potent inhibitor of HIF-1 prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

top caption :

Potent, selective HIF-1 prolyl hydroxylase-2 (PHD2) inhibitor

extended description :

Potent, selective HIF-1 prolyl hydroxylase-2 (PHD2) inhibitor

chemical name text :

N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine

formula :

C19H16N2O5

formula text :

C19H16N2O5

cas num :

931398-72-0

USD :

286 USD

product details :

Potent, selective HIF-1 prolyl hydroxylase-2 (PHD2) inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage