PFI 1 | Tocris Bioscience 4445/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PFI 1

catalog :

4445/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Ortiz Barahona V, Soler M, Davalos V, Garc xed a Prieto C, Janin M, Setien F, et al. Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer. Mol Cancer. 2023;22:83 pubmed publisher
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher
Clifford R, Patel J, John A, Tatler A, Mazengarb L, Brightling C, et al. CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET. Am J Physiol Lung Cell Mol Physiol. 2015;308:L962-72 pubmed publisher
Fish P, Filippakopoulos P, Bish G, Brennan P, Bunnage M, Cook A, et al. Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012;55:9831-7 pubmed publisher

product information

brand :

Tocris

master code :

4445

SKU :

4445/10

product name :

PFI 1

unit size :

10 mg (also 50 mg)

seo description :

BET bromodomain inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

347.39

url print :

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details of functionality :

PFI 1 is a potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC50 values are 98 and 220 nM respectively). Induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable.

top caption :

BET bromodomain inhibitor

extended description :

BET bromodomain inhibitor

chemical name text :

2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide

formula :

C16H17N3O4S

formula text :

C16H17N3O4S

cas num :

1403764-72-6

USD :

246 USD

product details :

BET bromodomain inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage