Fatostatin A | Tocris Bioscience 4444/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fatostatin A

catalog :

4444/10

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Alice A, Kramer G, Bambina S, Bahjat K, Gough M, Crittenden M. Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production. Sci Rep. 2021;11:16347 pubmed publisher
Yi J, Zhu J, Wu J, Thompson C, Jiang X. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc Natl Acad Sci U S A. 2020;117:31189-31197 pubmed publisher
Triki M, Rinaldi G, Planque M, Broekaert D, Winkelkotte A, Maier C, et al. mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis. Cell Rep. 2020;31:107806 pubmed publisher
Kusnadi A, Park S, Yuan R, Pannellini T, Giannopoulou E, Oliver D, et al. The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Immunity. 2019;51:241-257.e9 pubmed publisher
Cornacchia D, Zhang C, Zimmer B, Chung S, Fan Y, Soliman M, et al. Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs. Cell Stem Cell. 2019;: pubmed publisher
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
Abshire C, Dragoi A, Roy C, Ivanov S. MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS Pathog. 2016;12:e1006088 pubmed publisher
Misra U, Pizzo S. Activated Î±2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. J Biol Chem. 2015;290:9571-87 pubmed publisher

product information

brand :

Tocris

master code :

4444

SKU :

4444/10

product name :

Fatostatin A

unit size :

10 mg (also 50 mg)

seo description :

Cell permeable inhibitor of SREBP activation

target :

SREBP Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

375.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 M); reverses hyperglycemia in diabetic ( ob/ob ) mice. Cell permeable.

top caption :

Cell permeable inhibitor of SREBP activation

extended description :

Cell permeable inhibitor of SREBP activation

chemical name text :

4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide

formula :

C18H18N2S.HBr

formula text :

C18H18N2S.HBr

cas num :

298197-04-3

USD :

159 USD

product details :

Cell permeable inhibitor of SREBP activation

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage