ISX 9 | Tocris Bioscience 4439 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ISX 9

catalog :

4439

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Xie X, Jankauskas R, Mazari A, Drou N, Percipalle P. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet. 2018;14:e1007846 pubmed publisher
Pujol J, Heikkila E, Savoia C, Hajibeigi A, De Marchi U, Battiprolu P, et al. Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci. 2018;19: pubmed publisher
Koh S, Liang A, Takahashi Y, Maki T, Shindo A, Osumi N, et al. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS ONE. 2015;10:e0138724 pubmed publisher

product information

brand :

Tocris

master code :

4439

SKU :

4439/10

product name :

ISX 9

description :

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

target :

Compounds for Stem Cell Differentiation

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

234.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro .

catalog number base :

4439

product keywords :

ISX9 isoxazoles neurogenic neuronal differentiation neuroD1 CaMKII MEF2 neurogenesis Isx1 Neuronal differentiator inducer III Neural Stem Cells Cardiomyocyte Stem Cells 4439, differentiation stem cells, DIFFERENTIATION STEM CELLS

extended description :

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

chemical name text :

N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

formula :

C 11 H 10 N 2 O 2 S

formula text :

C11H10N2O2S

cas num :

832115-62-5

2020 USD :

182

2021 USD :

190 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage