ISX 9 | Tocris Bioscience 4439/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ISX 9

catalog :

4439/10

quantity :

10 mg (also 50 mg)

price :

220 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Xie X, Jankauskas R, Mazari A, Drou N, Percipalle P. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet. 2018;14:e1007846 pubmed publisher
Pujol J, Heikkila E, Savoia C, Hajibeigi A, De Marchi U, Battiprolu P, et al. Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci. 2018;19: pubmed publisher
Koh S, Liang A, Takahashi Y, Maki T, Shindo A, Osumi N, et al. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS ONE. 2015;10:e0138724 pubmed publisher

product information

brand :

Tocris

master code :

4439

SKU :

4439/10

rank :

0.061

product name :

ISX 9

description :

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

target :

Compounds for Stem Cell Differentiation

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ISX 9 is a neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro . . ISX 9 synthesized to Ancillary Material Grade also available. . For more information about how ISX 9 may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons .

extended description :

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

chemical name text :

N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

formula :

C 11 H 10 N 2 O 2 S

formula text :

C11H10N2O2S

cas num :

832115-62-5

USD :

220 USD

product details :

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage