8-Chloroadenosine | Tocris Bioscience 4436 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8-Chloroadenosine

catalog :

4436

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kearney A, Fan Y, Giri U, Saigal B, Gandhi V, Heymach J, et al. 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLoS ONE. 2015;10:e0135962 pubmed publisher

product information

brand :

Tocris

master code :

4436

SKU :

4436/10

product name :

8-Chloroadenosine

description :

Cytotoxic nucleoside analog; inhibits RNA synthesis

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

301.69

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

catalog number base :

4436

product keywords :

8-Cl-Ado 8-Cl-ATP cytotoxic chemotherapeutics growth arrest RNA synthesis transcription inhibitors inhibits nucleoside analogs DNA, RNA and Protein Synthesis Cell Cycle Inhibitors 4436,

extended description :

Cytotoxic nucleoside analog; inhibits RNA synthesis

chemical name text :

6-Amino-8-chloropurine riboside

formula :

C 10 H 12 ClN 5 O 4

formula text :

C10H12ClN5O4

cas num :

34408-14-5

2020 USD :

214

2021 USD :

219 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage