A 1070722 | Tocris Bioscience 4431 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 1070722

catalog :

4431

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4431

SKU :

4431/10

product name :

A 1070722

description :

Highly potent, selective GSK-3 inhibitor

target :

GSK-3 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

362.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3 and GSK-3 ). Displays high selectivity ( 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro ; protects rat primary cortical neurons against amyloid and glutamate challenge. Brain penetrant.

catalog number base :

4431

product keywords :

A1070722 glycogen synthase kinases 3 inhibits inhibitors potent selective brain penetrant neuroprotective tau phosphorylation beta b amyloid Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 4431,

extended description :

Highly potent, selective GSK-3 inhibitor

chemical name text :

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

formula :

C 17 H 13 F 3 N 4 O 2

formula text :

C17H13F3N4O2

cas num :

1384424-80-9

2020 USD :

205

2021 USD :

212 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage