DBeQ | Tocris Bioscience 4417/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DBeQ

catalog :

4417/10

quantity :

10 mg (also 50 mg)

price :

227 USD

citations: 2

Reference
Wrobel L, Hill S, Djajadikerta A, Fernandez Estévez M, Karabiyik C, Ashkenazi A, et al. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun. 2022;13:4146 pubmed publisher
Tiwari A, Copeland C, Han B, Hanson C, Raghunathan K, Kenworthy A. Caveolin-1 is an aggresome-inducing protein. Sci Rep. 2016;6:38681 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4417

SKU :

4417/10

product name :

DBeQ

Description :

Selective and reversible p97 ATPase inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

340.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 M). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

extended description :

Selective and reversible p97 ATPase inhibitor

chemical name text :

N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

formula :

C 22 H 20 N 4

formula text :

C22H20N4

cas num :

177355-84-9

USD :

227 USD

product details :

Selective and reversible p97 ATPase inhibitor

storage :

Store at +4°C