TP 003 | Tocris Bioscience 4414 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TP 003

catalog :

4414

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Söderhielm P, Balle T, Bak Nyhus S, Zhang M, Hansen K, Ahring P, et al. Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem Pharmacol. 2018;158:339-358 pubmed publisher
Seifi M, Rodaway S, Rudolph U, Swinny J. GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice. Gastroenterology. 2018;155:852-864.e3 pubmed publisher
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78 pubmed publisher

product information

brand :

Tocris

master code :

4414

SKU :

4414/10

product name :

TP 003

description :

GABAA partial agonist; acts at benzodiazepine site

target :

GABA-A Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

407.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GABAA receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABAA 3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABAA 2 subtype receptors. Also evokes GABAA 1 mediated sedation and GABAA 3 mediated muscle relaxation in mice.

catalog number base :

4414

product keywords :

TP003 GABAA GABA receptors a3 alpha3 3 agonists anxiolytic GABAA Receptors 4414,

extended description :

GABAA partial agonist; acts at benzodiazepine site

chemical name text :

2 ,4-Difluoro-5 -[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1 -biphenyl]-2-carbonitrile

formula :

C 23 H 16 F 3 N 3 O

formula text :

C23H16F3N3O

cas num :

628690-75-5

2020 USD :

205

2021 USD :

210 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage