SMIFH2 | Tocris Bioscience 4401/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SMIFH2

catalog :

4401/10

quantity :

10 mg (also 50 mg)

price :

157 USD

citations: 12

Reference
Mishra S, Levy D. Nuclear F-actin and Lamin A antagonistically modulate nuclear shape. J Cell Sci. 2022;135: pubmed publisher
Liu D, Fu X, Wang Y, Wang X, Wang H, Wen J, et al. Protein diaphanous homolog 1 (Diaph1) promotes myofibroblastic activation of hepatic stellate cells by regulating Rab5a activity and TGFβ receptor endocytosis. FASEB J. 2020;34:7345-7359 pubmed publisher
Alieva N, Efremov A, Hu S, Oh D, Chen Z, Natarajan M, et al. Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion. Nat Commun. 2019;10:3593 pubmed publisher
Moreau H, Blanch Mercader C, Attia R, Maurin M, Alraies Z, Sanséau D, et al. Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration. Dev Cell. 2019;: pubmed publisher
Ray P, Chin A, Worley K, Fan J, Kaur G, Wu M, et al. Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping. Proc Natl Acad Sci U S A. 2018;115:E11568-E11577 pubmed publisher
Ford C, NANS A, Boucrot E, Hayward R. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog. 2018;14:e1007051 pubmed publisher
LeCorgne H, Tudosie A, Lavik K, Su R, Becker K, Moore S, et al. Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish. Front Pharmacol. 2018;9:340 pubmed publisher
Sepúlveda Ramírez S, Toledo Jacobo L, Henson J, Shuster C. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol. 2018;437:140-151 pubmed publisher
Logue J, Cartagena Rivera A, Chadwick R. c-Src activity is differentially required by cancer cell motility modes. Oncogene. 2018;37:2104-2121 pubmed publisher
Basu S, Kustanovich I, Lamprecht R. Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala. Eneuro. 2016;3: pubmed
Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, et al. A dynamic formin-dependent deep F-actin network in axons. J Cell Biol. 2015;210:401-17 pubmed publisher
Tornavaca O, Chia M, Dufton N, Almagro L, Conway D, Randi A, et al. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. J Cell Biol. 2015;208:821-38 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4401

SKU :

4401/10

product name :

SMIFH2

Description :

FH2 domain inhibitor; prevents actin nucleation

target :

Actin-related Products

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

377.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.

extended description :

FH2 domain inhibitor; prevents actin nucleation

chemical name text :

1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

formula :

C 15 H 9 BrN 2 O 3 S

formula text :

C15H9BrN2O3S

cas num :

340316-62-3

USD :

157 USD

product details :

FH2 domain inhibitor; prevents actin nucleation

storage :

Store at +4°C