chemical

GNF 2

4399

10 mg (also 50 mg)

235 USD

4399

4399/10

GNF 2

Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity

Abl Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

374.32

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Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

4399

GNF2 bcrabl bcr abl fusion philadelphia chromosome antiproliferatives apoptosis inducers chronic myeloid leukemia leukaemia allosteric inhibits inhibitors selective Abl Kinase 4399,

Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity

3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

C 18 H 13 F 3 N 4 O 2

C18H13F3N4O2

778270-11-4

235

235 USD

Store at +4°C