AV 412 | Tocris Bioscience 4397 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AV 412

catalog :

4397

quantity :

10 mg

price :

228 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4397

SKU :

4397/10

product name :

AV 412

description :

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

507

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.

catalog number base :

4397

product keywords :

AV412 epidermal growth factor receptor tyrosine kinases EGFR ErbB2 RTKs inhibitors inhibits potent Abl EGFR 4397,

extended description :

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

chemical name text :

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide

formula :

C 27 H 28 ClFN 6 O

formula text :

C27H28ClFN6O

cas num :

451492-95-8

2020 USD :

284

2021 USD :

228 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage