680C91 | Tocris Bioscience 4392 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

680C91

catalog :

4392

quantity :

25 mg

price :

406 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Breda C, Sathyasaikumar K, Sograte Idrissi S, Notarangelo F, Estranero J, Moore G, et al. Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites. Proc Natl Acad Sci U S A. 2016;113:5435-40 pubmed publisher
Bostian A, Maddukuri L, Reed M, Savenka T, Hartman J, Davis L, et al. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016;29:101-8 pubmed publisher
D Amato N, Rogers T, Gordon M, Greene L, Cochrane D, Spoelstra N, et al. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015;75:4651-64 pubmed publisher

product information

brand :

Tocris

master code :

4392

SKU :

4392/25

product name :

680C91

description :

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

target :

Tryptophan 2,3 Dioxygenase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

238.26

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.

catalog number base :

4392

product keywords :

tryptophan 2,3-dioxygenase inhibits TDO inhibitors tryptophan catabolism Tryptophan 2,3 dioxygenase Immune Checkpoints 4392,

extended description :

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

chemical name text :

6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

formula :

C 15 H 11 FN 2

formula text :

C15H11FN2

cas num :

163239-22-3

2020 USD :

390

2021 USD :

406 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage