680C91 | Tocris Bioscience 4392/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

680C91

catalog :

4392/5

quantity :

5 mg (also 25 mg)

price :

121 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Reed M, Maddukuri L, Ketkar A, Byrum S, Zafar M, Bostian A, et al. Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. NAR Cancer. 2021;3:zcab014 pubmed publisher
Takenaka M, Gabriely G, Rothhammer V, Mascanfroni I, Wheeler M, Chao C, et al. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019;22:729-740 pubmed publisher
Breda C, Sathyasaikumar K, Sograte Idrissi S, Notarangelo F, Estranero J, Moore G, et al. Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites. Proc Natl Acad Sci U S A. 2016;113:5435-40 pubmed publisher
Bostian A, Maddukuri L, Reed M, Savenka T, Hartman J, Davis L, et al. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016;29:101-8 pubmed publisher
D Amato N, Rogers T, Gordon M, Greene L, Cochrane D, Spoelstra N, et al. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015;75:4651-64 pubmed publisher
Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, et al. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. J Transl Med. 2012;10:247 pubmed publisher

image

image 1 :

Cat.No. 4392 - 680C91 C15H11FN2 CAS No. 163239-22-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4392

SKU :

4392/5

product name :

680C91

description :

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

target :

Tryptophan 2,3 Dioxygenase Inhibitors

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

238.26

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.

product keywords :

tryptophan 2,3-dioxygenase inhibits TDO inhibitors tryptophan catabolism immune checkpoints Tryptophan 2,3 dioxygenase Immune Checkpoints 4392,

extended description :

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

chemical name text :

6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

formula :

C15H11FN2

formula text :

C15H11FN2

cas num :

163239-22-3

USD :

134

USD 2025 :

121 USD

product details :

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

more info or order :

Tocris Bioscience product webpage