Thiamet G | Tocris Bioscience 4390 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Thiamet G

catalog :

4390

quantity :

10 mg

price :

273 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Taparra K, Wang H, Malek R, Lafargue A, Barbhuiya M, Wang X, et al. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest. 2018;128:4924-4937 pubmed publisher
Maury J, Chan K, Zheng L, Bardor M, Choo A. Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation. Stem Cell Res. 2013;11:926-37 pubmed publisher
Hayakawa K, Hirosawa M, Tabei Y, Arai D, Tanaka S, Murakami N, et al. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. J Biol Chem. 2013;288:17099-110 pubmed publisher

product information

brand :

Tocris

master code :

4390

SKU :

4390/10

product name :

Thiamet G

description :

Potent O-GlcNAcase inhibitor

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

10 mg

observed molecular weight :

248.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective inhibitor of O -GlcNAcase (Ki = 21 nM for human O -GlcNAcase). Decreases the phosphorylation of tau protein in vivo . Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

catalog number base :

4390

product keywords :

glycosidase O-GlcNAc-beta-N-acetylglucosaminidase inhibitors inhibits O-GlcNAcase ThiametG Other Hydrolases 4390,

extended description :

Potent O-GlcNAcase inhibitor

chemical name text :

(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

formula :

C 9 H 16 N 2 O 4 S

formula text :

C9H16N2O4S

cas num :

1009816-48-1

2020 USD :

262

2021 USD :

273 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage