Calhex 231 hydrochloride | Tocris Bioscience 4387/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Calhex 231 hydrochloride

catalog :

4387/10

quantity :

10 mg (also 50 mg)

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Dowsett L, Duluc L, Higgins E, Alghamdi F, Fast W, Salt I, et al. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cell Signal. 2023;107:110676 pubmed publisher
Thrum S, Sommer M, Raulien N, Gericke M, Massier L, Kovacs P, et al. Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals. Int J Obes (Lond). 2022;46:1883-1891 pubmed publisher
Markworth R, Adolfs Y, Dambeck V, Steinbeck L, Lizé M, Pasterkamp R, et al. Sensory axon growth requires spatiotemporal integration of CaSR and TrkB signalling. J Neurosci. 2019;: pubmed publisher
Yarova P, Stewart A, Sathish V, Britt R, Thompson M, P Lowe A, et al. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015;7:284ra60 pubmed publisher
Diakogiannaki E, Pais R, Tolhurst G, Parker H, Horscroft J, Rauscher B, et al. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 2013;56:2688-96 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4387

SKU :

4387/10

product name :

Calhex 231 hydrochloride

description :

Negative allosteric modulator of calcium-sensing receptor (CaSR)

target :

Calcium-Sensing Receptor Modulators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

443.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [3H]inositol phosphate levels elicited by wild-type hCasR activation (IC50= 0.39 M in transiently transfected HEK293 cells).

product keywords :

Calhex231 calcilytics hcasr calcium-sensing receptors negative allosteric modulators nams Calcium-Sensing Receptor 4387,

extended description :

Negative allosteric modulator of calcium-sensing receptor (CaSR)

chemical name text :

4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

formula :

C25H27ClN2O.HCl

formula text :

C25H27ClN2O.HCl

cas num :

2387505-78-2

USD :

317

USD 2025 :

286 USD

product details :

Negative allosteric modulator of calcium-sensing receptor (CaSR)

more info or order :

Tocris Bioscience product webpage