Donepezil hydrochloride | Tocris Bioscience 4385/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Donepezil hydrochloride

catalog :

4385/10

quantity :

10 mg (also 50 mg)

price :

97 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Serrano M, Herrero Labrador R, Futch H, Serrano J, Romero A, Fernández A, et al. The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease. J Psychiatry Neurosci. 2017;42:59-69 pubmed
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
Morris M, Sanchez P, Verret L, Beagle A, Guo W, Dubal D, et al. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol. 2015;2:1012-28 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4385

SKU :

4385/10

product name :

Donepezil hydrochloride

description :

Potent AChE inhibitor

target :

Cholinesterase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Desiccate at RT

observed molecular weight :

415.95

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Donepezil hydrochloride is a potent and selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). In animal models of Alzheimer s disease, Donepezil reduces brain tissue A protein and plaque deposition, restores normal glucose metabolism, reduces neuroinflammation and rescues cognitive dysfunction and memory deficits. The pro-cognitive effects are potentiated by combination with Mefloquine (Cat. No. 6819). In vitro Donepezil reduces LPS-induced inflammation and protects against mitochondrial membrane potential damage.

product keywords :

acetylcholinesterase ache selective potent inhibitors inhibits E2020 ache neurodegeneration alzheimers amyloid beta AB neuroinflammation A E 2020 Cholinesterases 4385,

extended description :

Potent AChE inhibitor

chemical name text :

2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

formula :

C24H29NO3.HCl

formula text :

C24H29NO3.HCl

cas num :

120011-70-3

USD :

USD 2025 :

97 USD

product details :

Potent AChE inhibitor

alt names :

E 2020

more info or order :

Tocris Bioscience product webpage