VU 0285683 | Tocris Bioscience 4381 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0285683

catalog :

4381

quantity :

10 mg (also 50 mg)

price :

175 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4381

SKU :

4381/10

product name :

VU 0285683

description :

Negative allosteric modulator of mGlu5 receptors

target :

Group I mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

266.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).

catalog number base :

4381

product keywords :

Negative allosteric modulators mGlu5 mGluR5 mGlur Group I Receptors Glutamate Metabotropic MPEP binding site VU0285683 nams Glutamate (Metabotropic) Group I Receptors 4381,

extended description :

Negative allosteric modulator of mGlu5 receptors

chemical name text :

3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

formula :

C 14 H 7 FN 4 O

formula text :

C14H7FN4O

cas num :

327056-22-4

2020 USD :

171

2021 USD :

175 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage