product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
WAY 100635 maleate
catalog :
4380
quantity :
10 mg (also 50 mg)
price :
186 USD
more info or order :
citations: 9
Reference
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed publisher
Nguyen H, Cho D, Jang S, Han S, Park S. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019;23:271-279 pubmed publisher
Walory J, Mielczarek L, Jarończyk M, Koronkiewicz M, Kossakowski J, Bugno R, et al. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci. 2018;19: pubmed publisher
Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Higashi Y, et al. Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats. Br J Pharmacol. 2017;174:3072-3080 pubmed publisher
Yin L, Rasch M, He Q, Wu S, Dou F, Shu Y. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex. 2017;27:509-521 pubmed publisher
Wieronska J, Sławińska A, Łasoń Tyburkiewicz M, Gruca P, Papp M, Zorn S, et al. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Psychopharmacology (Berl). 2015;232:259-73 pubmed publisher
Rawls S, Shah H, Ayoub G, Raffa R. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett. 2010;484:113-7 pubmed publisher
Greene J, Banasr M, Lee B, Warner Schmidt J, Duman R. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization. Neuropsychopharmacology. 2009;34:2459-68 pubmed publisher
product information
brand :
Tocris
master code :
4380
SKU :
4380/10
product name :
WAY 100635 maleate
description :
Potent 5-HT1A antagonist; also D4 agonist
target :
5-HT1A Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
538.64
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
catalog number base :
4380
product keywords :
WAY100635 maleate 5-ht1a serotonin serotonergics selective antagonists dopamine D4 antagonists dopaminergics 634908-75-1 5-HT1A Receptors D4 Receptors 4380,
extended description :
Potent 5-HT1A antagonist; also D4 agonist
chemical name text :
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
formula :
C 25 H 34 N 4 O 2 .C 4 H 4 O 4
formula text :
C25H34N4O2.C4H4O4
cas num :
1092679-51-0
2020 USD :
178
2021 USD :
186 USD
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK