product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
WAY 100635 maleate
catalog :
4380/10
quantity :
10 mg (also 50 mg)
price :
246 USD
more info or order :
citations: 13
Reference
Śniecikowska J, Gluch Lutwin M, Bucki A, Wi x119 ckowska A, Siwek A, Jastrzebska Wiesek M, et al. Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile. J Med Chem. 2020;63:10946-10971 pubmed publisher
Gantz S, Moussawi K, Hake H. Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. elife. 2020;9: pubmed publisher
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed publisher
Prasad S, Ponimaskin E, Zeug A. Serotonin receptor oligomerization regulates cAMP-based signaling. J Cell Sci. 2019;132: pubmed publisher
Nguyen H, Cho D, Jang S, Han S, Park S. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019;23:271-279 pubmed publisher
Sengupta A, Holmes A. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron. 2019;: pubmed publisher
Walory J, Mielczarek L, Jarończyk M, Koronkiewicz M, Kossakowski J, Bugno R, et al. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci. 2018;19: pubmed publisher
Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Higashi Y, et al. Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats. Br J Pharmacol. 2017;174:3072-3080 pubmed publisher
Yin L, Rasch M, He Q, Wu S, Dou F, Shu Y. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex. 2017;27:509-521 pubmed publisher
Wieronska J, Sławińska A, Łasoń Tyburkiewicz M, Gruca P, Papp M, Zorn S, et al. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Psychopharmacology (Berl). 2015;232:259-73 pubmed publisher
Rawls S, Shah H, Ayoub G, Raffa R. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett. 2010;484:113-7 pubmed publisher
Greene J, Banasr M, Lee B, Warner Schmidt J, Duman R. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization. Neuropsychopharmacology. 2009;34:2459-68 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
4380
SKU :
4380/10
product name :
WAY 100635 maleate
description :
Potent 5-HT1A antagonist; also D4 agonist
target :
5-HT1A Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Desiccate at RT
observed molecular weight :
538.64
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
product keywords :
WAY100635 maleate 5-ht1a serotonin serotonergics selective antagonists dopamine D4 antagonists dopaminergics 634908-75-1 5-HT1A Receptors D4 Receptors 4380,
extended description :
Potent 5-HT1A antagonist; also D4 agonist
chemical name text :
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
formula :
C25H34N4O2.C4H4O4
formula text :
C25H34N4O2.C4H4O4
cas num :
1092679-51-0
USD :
236
USD 2025 :
246 USD
product details :
Potent 5-HT1A antagonist; also D4 agonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK