Crizotinib | Tocris Bioscience 4368 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Crizotinib

catalog :

4368

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Maru Y, Tanaka N, Ebisawa K, Odaka A, Sugiyama T, Itami M, et al. Establishment and characterization of patient-derived organoids from a young patient with cervical clear cell carcinoma. Cancer Sci. 2019;110:2992-3005 pubmed publisher
Giménez Xavier P, Pros E, Aza A, Moran S, Tonda R, Esteve Codina A, et al. Deep analysis of acquired resistance to FGFR1 inhibitor identifies MET and AKT activation and an expansion of AKT1 mutant cells. Oncotarget. 2018;9:31549-31558 pubmed publisher
Ayoub N, Al Shami K, Alqudah M, Mhaidat N. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 2017;10:4869-4883 pubmed publisher
Giménez Xavier P, Pros E, Bonastre E, Moran S, Aza A, Grana O, et al. Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells. Mol Cancer Ther. 2017;16:1366-1376 pubmed publisher
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene. 2016;35:5388-5399 pubmed publisher
Sullivan K, Padilla Just N, Henry R, Porter C, Kim J, Tentler J, et al. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol. 2012;8:646-54 pubmed publisher
Qi J, MCTIGUE M, Rogers A, Lifshits E, Christensen J, JÃ¤nne P, et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res. 2011;71:1081-91 pubmed publisher

product information

brand :

Tocris

master code :

4368

SKU :

4368/10

product name :

Crizotinib

description :

Potent c-MET/ALK inhibitor

target :

MET Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

450.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against 120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro . Orally bioavailable.

catalog number base :

4368

product keywords :

c-MET alk anaplastic lymphoma kinases antitumor selective potent PF2341066 PF02341066 PF 02341066 PF 2341066 MET Receptors ALK 4368,

extended description :

Potent c-MET/ALK inhibitor

chemical name text :

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

formula :

C 21 H 22 Cl 2 FN 5 O

formula text :

C21H22Cl2FN5O

cas num :

877399-52-5

2020 USD :

270

2021 USD :

281 USD

alt names :

PF 02341066, PF 2341066

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage