SAG | Tocris Bioscience 4366 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SAG

catalog :

4366

quantity :

1 mg

price :

167 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Haidar M, Asselbergh B, Adriaenssens E, de Winter V, Timmermans J, Auer Grumbach M, et al. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy. 2019;15:1051-1068 pubmed publisher
Atzmon A, Herrero M, Sharet Eshed R, Gilad Y, Senderowitz H, Elroy Stein O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 2018;11:336 pubmed publisher
Rajamani U, Gross A, Hjelm B, Sequeira A, Vawter M, Tang J, et al. Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 2018;22:698-712.e9 pubmed publisher
Xia N, Zhang P, Fang F, Wang Z, Rothstein M, Angulo B, et al. Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci Rep. 2016;6:20270 pubmed publisher
Cortes M, Liu S, Kwan W, Alexa K, Goessling W, North T. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem Cell Reports. 2015;5:471-9 pubmed publisher

product information

brand :

Tocris

master code :

4366

SKU :

4366/1

product name :

SAG

description :

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

target :

Smoothened Receptor Agonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

490.06

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.

catalog number base :

4366

product keywords :

Potent Smoothened Smo receptors agonists activates Hedgehog signaling pathway activator enhancers neuronal differentiation iPCs inducible pluripotent stem cells dopaminergic neurons neurones Smoothened Receptors Hedgehog Signaling Neural Stem Cells ESCs and iPSC 4366,

extended description :

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

chemical name text :

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

formula :

C 28 H 28 ClN 3 OS

formula text :

C28H28ClN3OS

cas num :

912545-86-9

2020 USD :

163

2021 USD :

167 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage