SAG | Tocris Bioscience 4366/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SAG

catalog :

4366/1

quantity :

1 mg

price :

194 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Haidar M, Asselbergh B, Adriaenssens E, de Winter V, Timmermans J, Auer Grumbach M, et al. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy. 2019;15:1051-1068 pubmed publisher
Atzmon A, Herrero M, Sharet Eshed R, Gilad Y, Senderowitz H, Elroy Stein O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 2018;11:336 pubmed publisher
Rajamani U, Gross A, Hjelm B, Sequeira A, Vawter M, Tang J, et al. Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 2018;22:698-712.e9 pubmed publisher
Xia N, Zhang P, Fang F, Wang Z, Rothstein M, Angulo B, et al. Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci Rep. 2016;6:20270 pubmed publisher
Cortes M, Liu S, Kwan W, Alexa K, Goessling W, North T. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem Cell Reports. 2015;5:471-9 pubmed publisher

product information

brand :

Tocris

master code :

4366

SKU :

4366/1

rank :

0.061

product name :

SAG

description :

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

target :

Smoothened Receptor Agonists

category :

Small Molecules

sizes available :

1 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and nduces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. . SAG dihydrochloride (Cat. No. 6390) also available.

extended description :

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

chemical name text :

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

formula :

C 28 H 28 ClN 3 OS

formula text :

C28H28ClN3OS

cas num :

912545-86-9

USD :

194 USD

product details :

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage