Bosutinib | Tocris Bioscience 4361 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bosutinib

catalog :

4361

quantity :

10 mg (also 50 mg)

price :

279 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Levinson N, Boxer S. A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity. Nat Chem Biol. 2014;10:127-32 pubmed publisher
Levinson N, Boxer S. Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. PLoS ONE. 2012;7:e29828 pubmed publisher

product information

brand :

Tocris

master code :

4361

SKU :

4361/10

product name :

Bosutinib

description :

Dual Src-Abl inhibitor; antiproliferative

target :

Src Family Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

530.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

catalog number base :

4361

product keywords :

dual inhibitors inhibits abl src kinases antiproliferative SKI-606 Src Kinases Abl Kinase 4361,

extended description :

Dual Src-Abl inhibitor; antiproliferative

chemical name text :

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

formula :

C 26 H 29 Cl 2 N 5 O 3

formula text :

C26H29Cl2N5O3

cas num :

380843-75-4

2020 USD :

270

2021 USD :

279 USD

alt names :

SKI-606

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage